Protéine proleucémie myéloïde

La protéine proleucémie myéloïde (abrégée PML, de l'anglais Promyelocytic leukemia protein) est une protéine supresseur de tumeurs. Son gène , PML, est situé sur le chromosome 15 humain. Elle est indispensable dans l'assemblage de certains corps nucléaires qui existent au niveau de la chromatine à un nombre de 1 à 30 par noyau. Ces structures appelées corps nucléaires PML sont impliquées dans la régulation de plusieurs processus cellulaires, dont l'apoptose , la stabilité génique, et la division cellulaire. La mutation ou l'inactivation du gène codant la protéine proleucémie myéloïde est corrélé avec plusieurs cancers dont la leucémie aigüe myéloïde.

PML
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1BOR, 2MVW, 2MWX, 4WJN, 4WJO
Identifiants
Aliases	PML
IDs externes	OMIM: 102578 MGI: 104662 HomoloGene: 13245 GeneCards: PML
Position du gène (Homme) Chr. Chromosome 15 humain[1] Locus 15q24.1 Début 73,994,673 bp[1] Fin 74,047,827 bp[1]
Position du gène (Souris) Chr. Chromosome 9 (souris)[2] Locus 9 B|9 31.63 cM Début 58,125,359 bp[2] Fin 58,157,069 bp[2]
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans upper lobe of left lung endocol poumon droit subcutaneous adipose tissue right uterine tube right lobe of thyroid gland left lobe of thyroid gland left uterine tube nerf sural Glandes accessoires Fortement exprimé dans rate ganglion lymphatique parotide thymus moelle osseuse sang glande submandibulaire Jéjunum duodénum subcutaneous adipose tissue Plus de données d'expression de référence BioGPS n/a
Gene Ontology Fonction moléculaire SUMO binding cobalt ion binding liaison ion métal protein homodimerization activity zinc ion binding liaison protéique SMAD binding liaison ADN transcription coactivator activity protein heterodimerization activity ubiquitin protein ligase binding SUMO transferase activity Composant cellulaire cytoplasme cytosol endosome membrane nucléaire membrane noyau matrice nucléaire nucléole réticulum endoplasmique early endosome membrane intracellulaire nucléoplasme PML body membrane du réticulum endoplasmique extrinsic component of endoplasmic reticulum membrane hétérochromatine Processus biologique regulation of protein phosphorylation positive regulation of histone deacetylation intrinsic apoptotic signaling pathway in response to oxidative stress myeloid cell differentiation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of telomere maintenance via telomerase processus rythmique interferon-gamma-mediated signaling pathway negative regulation of telomerase activity positive regulation of telomere maintenance sénescence cellulaire regulation of cell adhesion defense response to virus intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process transforming growth factor beta receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of cell population proliferation positive regulation of defense response to virus by host apoptose response to cytokine cell fate commitment negative regulation of translation in response to oxidative stress regulation of transcription, DNA-templated common-partner SMAD protein phosphorylation branching involved in mammary gland duct morphogenesis extrinsic apoptotic signaling pathway positive regulation of fibroblast proliferation positive regulation of apoptotic signaling pathway endoplasmic reticulum calcium ion homeostasis transcription, DNA-templated PML body organization negative regulation of cell growth intrinsic apoptotic signaling pathway by p53 class mediator système immunitaire inné viral process response to gamma radiation response to UV regulation of calcium ion transport into cytosol positive regulation of protein localization to chromosome, telomeric region fibroblast migration Adressage des protéines processus du système immunitaire protein stabilization positive regulation of apoptotic process involved in mammary gland involution circadian regulation of gene expression regulation of MHC class I biosynthetic process regulation of circadian rhythm negative regulation of transcription, DNA-templated maintenance of protein location in nucleus cellular response to interleukin-4 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator response to hypoxia regulation of double-strand break repair intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress retinoic acid receptor signaling pathway negative regulation of angiogenesis negative regulation of ubiquitin-dependent protein catabolic process entrainment of circadian clock by photoperiod negative regulation of mitotic cell cycle positive regulation of MHC class I biosynthetic process positive regulation of transcription by RNA polymerase II regulation of signal transduction by p53 class mediator cellular response to leukemia inhibitory factor protein import into nucleus protein-containing complex assembly positive regulation of nucleic acid-templated transcription Sumoylation Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 5371 18854 Ensembl ENSG00000140464 ENSMUSG00000036986 UniProt P29590 Q60953 RefSeq (mRNA) NM_033250 NM_002675 NM_033238 NM_033239 NM_033240 NM_033244 NM_033246 NM_033247 NM_033249 NM_008884 NM_178087 NM_001311088 RefSeq (protéine) NP_002666 NP_150241 NP_150242 NP_150243 NP_150247 NP_150249 NP_150250 NP_150252 NP_150253 NP_001298017 NP_032910 NP_835188 Localisation (UCSC) Chr 15: 73.99 – 74.05 Mb Chr 9: 58.13 – 58.16 Mb Publication PubMed [3] [4]
Wikidata
Voir/Editer Humain Voir/Editer Souris