Pax6

PAX6
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2CUE, 6PAX
Identifiants
Aliases	PAX6
IDs externes	OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6
Position du gène (Homme)
Chr.	Chromosome 11 humain[1]
Fin	31,818,062 bp[1]
Position du gène (Souris)
Chr.	Chromosome 2 (souris)[2]
Fin	105,527,709 bp[2]
Expression génétique
	Fortement exprimé dans
	palpebral conjunctiva; ; éminence ganglionnaire; ; Vermis du cervelet; ; pont; ; external globus pallidus; ; Region I of hippocampus proper; ; gyrus frontal moyen; ; épithélium pigmentaire rétinien; ; Cortex entorhinal; ; putamen;
	Fortement exprimé dans
	corneal stroma; ; cristallin; ; épithélium cornéen; ; iris; ; îlot de Langerhans; ; corps ciliaire; ; conjunctival fornix; ; glande lacrymale; ; cerebellar cortex; ; cupole optique;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; liaison ADN; sequence-specific DNA binding; ubiquitin-protein transferase activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; liaison de chromatine; DNA-binding transcription factor activity; transcription factor binding; protein kinase binding; ubiquitin protein ligase binding; liaison d'histone acétyltransférase; co-SMAD binding; R-SMAD binding; HMG box domain binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; noyau; nucléoplasme; cytosol; intracellulaire;
Processus biologique	développement de l'œil; blood vessel development; morphogenèse d'un organe animal; regulation of transcription, DNA-templated; glucose homeostasis; transcription, DNA-templated; central nervous system development; response to wounding; différenciation cellulaire; cornea development in camera-type eye; negative regulation of neurogenesis; vue; iris morphogenesis; développent d'un organisme multicellulaire; neuron fate commitment; Ubiquitination; negative regulation of transcription by RNA polymerase II; establishment of mitotic spindle orientation; cell fate determination; migration d'un neurone; negative regulation of protein phosphorylation; positive regulation of neuroblast proliferation; lens development in camera-type eye; régionalisation; type B pancreatic cell differentiation; pancreatic A cell development; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; hedgehog; axonogenesis; Guidage axonal; développement cérébral; salivary gland morphogenesis; negative regulation of cell population proliferation; regulation of asymmetric cell division; dorsal/ventral axis specification; anterior/posterior pattern specification; dorsal/ventral pattern formation; régulation de l'expression des gènes; positive regulation of gene expression; pallium development; oligodendrocyte cell fate specification; cerebral cortex regionalization; forebrain dorsal/ventral pattern formation; commitment of neuronal cell to specific neuron type in forebrain; forebrain-midbrain boundary formation; telencephalon regionalization; pituitary gland development; habenula development; signal transduction involved in regulation of gene expression; keratinocyte differentiation; regulation of cell migration; positive regulation of epithelial cell differentiation; forebrain development; lacrimal gland development; protein localization to organelle; eye photoreceptor cell development; camera-type eye development; cell fate commitment; negative regulation of neuron differentiation; régulation positive de la transcription dépendante de l'ADN; positive regulation of transcription by RNA polymerase II; regulation of timing of cell differentiation; embryonic camera-type eye morphogenesis; astrocyte differentiation; negative regulation of epithelial cell proliferation; régulation de la neurogenèse; retina development in camera-type eye; cellular response to leukemia inhibitory factor; negative regulation of neural precursor cell proliferation; positive regulation of core promoter binding;
	Sources:Amigo / QuickGO
Orthologues
	5080
	18508
	ENSG00000007372
	ENSMUSG00000027168
	P26367
	P63015
NM_000280; NM_001127612; NM_001258462; NM_001258463; NM_001258464;
	NM_001258465; NM_001310158; NM_001310159; NM_001310160; NM_001310161; NM_001604
NM_001244198; NM_001244200; NM_001244201; NM_001244202; NM_013627;
	NM_001310144; NM_001310145; NM_001310146
NP_000271; NP_001121084; NP_001245391; NP_001245392; NP_001245393;
	NP_001245394; NP_001297087; NP_001297088; NP_001297089; NP_001297090; NP_001595; NP_001355816; NP_001355817; NP_001355818; NP_001355819; NP_001355820; NP_001355821; NP_001355822; NP_001355823; NP_001355828; NP_001355829; NP_001355830; NP_001355831; NP_001355832; NP_001355833; NP_001355834; NP_001355835; NP_001355836; NP_001355837; NP_001355838; NP_001355839; NP_001355840; NP_001355841; NP_001355842; NP_001355843; NP_001355844; NP_001355845; NP_001355846; NP_001355847; NP_001355848; NP_001355849; NP_001355850; NP_001355851; NP_001355852; NP_001355853; NP_001355854; NP_001355855; NP_001355856; NP_001355857; NP_001355858; NP_001355859
NP_001231127; NP_001231129; NP_001231130; NP_001231131; NP_001297073;
	NP_001297074; NP_001297075; NP_038655
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La protéine paired box 6 (Pax6) est un facteur de transcription notamment impliqué dans le développement des yeux. Elle est codée par le gène PAX6 situé sur le chromosome 11 humain.

Notes et références

(en) Cet article est partiellement ou en totalité issu de l’article de Wikipédia en anglais intitulé « PAX6 » (voir la liste des auteurs).

GRCh38: Ensembl release 89: ENSG00000007372 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027168 - Ensembl, May 2017
« Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
« Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

Portail de la biologie cellulaire et moléculaire

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007372 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027168 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine