Apoliprotéine C-I

APOC1
Structures disponibles
PDB	Recherche UniProt humaine: PDBe RCSB
Identifiants PDB
	1ALE, 1ALF, 1IOJ, 1OPP
Identifiants
Aliases	APOC1
IDs externes	OMIM: 107710 HomoloGene: 136749 GeneCards: APOC1
Position du gène (Homme)
Chr.	Chromosome 19 humain[1]
Fin	44,919,349 bp[1]
Expression génétique
	Fortement exprimé dans
	right lobe of liver; ; noyau accumbens; ; putamen; ; noyau caudé; ; poumon droit; ; rate; ; substantia nigra; ; hypothalamus; ; ganglion lymphatique; ; upper lobe of left lung;
	n/a
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding; phosphatidylcholine-sterol O-acyltransferase activator activity;
Composant cellulaire	Chylomicron; very-low-density lipoprotein particle; réticulum endoplasmique; high-density lipoprotein particle; région extracellulaire;
Processus biologique	lipid transport; chylomicron remnant clearance; negative regulation of fatty acid biosynthetic process; processus métabolique lipidique; positive regulation of cholesterol esterification; phospholipid efflux; cholesterol metabolic process; negative regulation of phosphatidylcholine catabolic process; plasma lipoprotein particle remodeling; negative regulation of very-low-density lipoprotein particle clearance; regulation of cholesterol transport; negative regulation of receptor-mediated endocytosis; high-density lipoprotein particle remodeling; cholesterol efflux; negative regulation of cholesterol transport; negative regulation of lipoprotein lipase activity; very-low-density lipoprotein particle assembly; negative regulation of lipid catabolic process; triglyceride metabolic process; negative regulation of lipid metabolic process; positive regulation of catalytic activity; very-low-density lipoprotein particle clearance; lipoprotein metabolic process;
	Sources:Amigo / QuickGO
Orthologues
	341
	n/a
	ENSG00000130208
	n/a
	P02654
	n/a
	NM_001645; NM_001321065; NM_001321066; NM_001379687
	n/a
	NP_001307994; NP_001307995; NP_001636; NP_001366616
	n/a
	Wikidata
Voir/Editer Humain

L'apolipoprotéine C-I est l'une des quatre apolipoprotéine C. Son gène est APOC1 situé sur le chromosome 19 humain.

Rôle

Il inhibe la capture hépatique des VLDL[3], augmentant le taux sanguin de ce dernier.

En médecine

Son taux est corrélé avec celui des triglycérides sanguins et la présence d'un athérome carotidien[4].

Notes et références

GRCh38: Ensembl release 89: ENSG00000130208 - Ensembl, May 2017
« Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
Jong MC, Dahlmans VE, van Gorp PJ et al. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway, J Clin Invest, 1996;98:2259–2267
Hansen JB, Fernández JA, Notø AT, Dequchi H, Björkegren J, Mathiesen EB, The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis, J Lipids, 2011;2011:271062

Portail de la médecine
Portail de la biologie cellulaire et moléculaire

Cet article est issu de Wikipedia. Le texte est sous licence Creative Commons – Attribution – Partage à l’identique. Des conditions supplémentaires peuvent s’appliquer aux fichiers multimédias.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130208 - Ensembl, May 2017

[2] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Jong_1996-3] Jong MC, Dahlmans VE, van Gorp PJ et al. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway, J Clin Invest, 1996;98:2259–2267

[Hansen_2011-4] Hansen JB, Fernández JA, Notø AT, Dequchi H, Björkegren J, Mathiesen EB, The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis, J Lipids, 2011;2011:271062